2-(Tributylstannyl)-1,3-thiazole → HCID 67215433, compound

HRID 1663010Notes

Reaction equation

HRID 1663010 reaction equation
[C:1]([C:5]1[CH:35]=[CH:34][C:8]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([CH2:20][C:21]3[CH:22]=[N:23][C:24]([O:32][CH3:33])=[C:25]([C:27]4OC=CC=4)[CH:26]=3)=[N:12][N:11]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(C1C=CC(NC2C3C(=CC=CC=3)C(CC3C=NC(OC)=C(Br)C=3)=NN=2)=CC=1)(C)(C)C.C([Sn](CCCC)(CCCC)C1[S:73][CH:74]=[CH:75][N:76]=1)CCC>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([CH2:20][C:21]3[CH:22]=[N:23][C:24]([O:32][CH3:33])=[C:25]([C:27]4[S:73][CH:74]=[CH:75][N:76]=4)[CH:26]=3)=[N:12][N:11]=2)=[CH:34][CH:35]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 67215339HCID 67215339, compoundHCID 67215494HCID 67215494, compound

Product 1

HCID 67215433HCID 67215433, compound

Procedure

Can be obtained analogously to Ex. 18a from 1-(4-tert-butyl-anilino)-4-[5-bromo-6-methoxy-(pyridin-3-yl)-methyl]phthalazine and 2-tributylstannyl-thiazol (supplier: Frontier Scientific; Logan/USA). MS: (M+H)+=482; HPLC(Grad20-100) tRet=14.6.

Workup

  1. customCan be obtained analogously to Ex

Sources & evidence

ORD record
ord-039d78e97fe241779215a1b4ec1d40d3
Source dataset
uspto-grants-2011_10
Patent number
US08034814B2

Reaction notes

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