HCID 67215457, compound → HCID 178463265, compound

HRID 1663011Notes

Reaction equation

HRID 1663011 reaction equation
[C:1]([C:5]1[CH:33]=[CH:32][C:8]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([CH2:20][C:21]3[CH:22]=[N:23][C:24]([O:30]C)=[C:25]([NH:27][CH2:28][CH3:29])[CH:26]=3)=[N:12][N:11]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>C(Cl)(Cl)Cl>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([CH2:20][C:21]3[CH:22]=[N:23][C:24]([OH:30])=[C:25]([NH:27][CH2:28][CH3:29])[CH:26]=3)=[N:12][N:11]=2)=[CH:32][CH:33]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 1

HCID 67215457HCID 67215457, compound

Product 1

HCID 178463265HCID 178463265, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In analogy to Ex. 3, treatment of a solution of 1-(4-tert-butyl-anilino)-4-[5-ethylamino-6-methoxy-(pyridin-3-yl)-methyl]phthalazine in CHCl3 with Me3Sil, followed by hydrolysis gives the title compound. ES-MS: (M+H)+=428; HPLC(Grad20-100) tRet=11.9.

Sources & evidence

ORD record
ord-47f9bc36a55d4a30860ad26e3c3768ec
Source dataset
uspto-grants-2011_10
Patent number
US08034814B2

Reaction notes

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