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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1663013Generated: October 28, 2026

Potassium Carbonate → 1-(4-fluoro-2-methyl-1H-indol-5-yloxy)-4-[6-methoxy-(pyridin-3-yl)-methyl]phthalazine

https://huagongshe.com/reaction/1663013

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant4-fluoro-2-methyl-1H-indol-5-olHCID 10352036—
Reactant1-Chloro-4-[6-methoxy-(pyridin-3-yl)-methyl]phthalazineHCID 86628788—
SolventDimethylformamideHCID 6228—
Product1-(4-fluoro-2-methyl-1H-indol-5-yloxy)-4-[6-methoxy-(pyridin-3-yl)-methyl]phthalazineHCID 67215295—

Reaction Steps

Heating of a mixture of 1-chloro-4-[6-methoxy-(pyridin-3-yl)-methyl]phthalazine (Ex. 3e), 4-fluoro-5-hydroxy-2-methyl-1H-indole (preparation see WO 00/47212; Ex. 237) and K2CO3 in DMF yields the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08034814B2
Source datasetuspto-grants-2011_10
ORD IDord-6ebbe1a1ff9a439290dbeb2ce0901dd5
Source noteuspto-grants-2011_10