HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-N-methyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Fluorobenzenesulfonyl chloride | HCID 9588 | — |
| Reactant | N-methyl-1,4-dioxaspiro(4.5)decan-8-amine | HCID 16786570 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-N-methyl-benzenesulfonamide | HCID 67435736 | 70.8% |
Reaction Steps
A solution of (1,4-dioxa-spiro[4.5]dec-8-yl)-methyl-amine (1.5 g, 9 mmol), CH2Cl2 (50 mL), and Et3N (1.7 mL, 12 mmol) was stirred with 4-fluorobenzene sulfonyl chloride (1.7 g, 9 mmol) at room temperature. After 1 hour, the reaction mixture was concentrated and the residue purified by flash chromatography on silica gel to afford 2.1 g of N-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-N-methyl-benzenesulfonamide. Mass spectrometric data [M+H]+=330.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034826B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-03f67237ec284163a806f792a848a93c |
| Source note | uspto-grants-2011_10 |