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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1663021Generated: October 28, 2026

Hydrochloric Acid → HCID 45101536, compound

https://huagongshe.com/reaction/1663021

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantMethanolHCID 887—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 67436034HCID 67436034—
SolventTetrahydrofuranHCID 8028—
ProductHCID 45101536HCID 4510153610.6%

Reaction Steps

A solution of {8-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[3,2-b]indol-5-yl}-acetic acid tert-butyl ester (43 mg, 0.9 mmol) was dissolved in THF (1 mL), MeOH (1 mL) and 1N NaOH (0.2 mL). After 24 hours, the reaction mixture was neutralized with 1N HCl and concentrated to afford 40 mg of {8-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[3,2-b]indol-5-yl}-acetic acid. Mass spectrometric data [M+H]+=418.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08034826B2
Source datasetuspto-grants-2011_10
ORD IDord-6f30fb126f734539b85afd7bd60c945a
Source noteuspto-grants-2011_10