HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 45101536, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 67436034 | HCID 67436034 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 45101536 | HCID 45101536 | 10.6% |
Reaction Steps
A solution of {8-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[3,2-b]indol-5-yl}-acetic acid tert-butyl ester (43 mg, 0.9 mmol) was dissolved in THF (1 mL), MeOH (1 mL) and 1N NaOH (0.2 mL). After 24 hours, the reaction mixture was neutralized with 1N HCl and concentrated to afford 40 mg of {8-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[3,2-b]indol-5-yl}-acetic acid. Mass spectrometric data [M+H]+=418.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034826B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-6f30fb126f734539b85afd7bd60c945a |
| Source note | uspto-grants-2011_10 |