HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidineethanol → HCID 21096914, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidineethanol | HCID 73953 | — |
| Reactant | Isoquinoline, 1-chloro- | HCID 140539 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 21096914 | HCID 21096914 | — |
Reaction Steps
4.17 g (25.50 mmol) of 1-chloroisoquinoline, 3.62 g (28 mmol) of 2-(4-piperidyl)ethanol, 5.90 g (61.20 mmol) of sodium tert-butoxide and 0.476 g (0.765 mmol) of BINAP (2,2′-bis(diphenylphosphino)-1,1′-binaphthyl) suspended in 50 ml of toluene are introduced under an inert atmosphere. 0.233 g (0.255 mmol) of tris(dibenzylideneacetone)dipalladium is then added. The reaction mixture is then refluxed for 12 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034818B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-3591638cf5c643aa9ec0329a7fe969ad |
| Source note | uspto-grants-2011_10 |