Ammonia → HCID 58861249, compound

HRID 1663035Notes

Reaction equation

HRID 1663035 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][N:20]3[C:24](=[O:25])[CH2:23][O:22][C:21]3=[O:26])[CH2:14][CH2:13]1)=[N:7][CH:6]=[CH:5]2.[NH3:27]>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][NH:20][C:21](=[O:26])[O:22][CH2:23][C:24]([NH2:27])=[O:25])[CH2:14][CH2:13]1)=[N:7][CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21096967HCID 21096967, compound

Product 1

HCID 58861249HCID 58861249, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The process is performed according to the procedure described in Example 3 (step 3.4). Starting with 0.597 g (1.67 mmol) of 3-{2-[1-(6-fluoro-1-isoquinolyl)-4-piperidyl]ethyl}-1,3-oxazolidine-2,4-dione, obtained in Step 6.3, and 14.30 ml (100.20 mmol) of a solution (7M) of aqueous ammonia in methanol, and after chromatography on silica gel, eluting with a 95/5 mixture of dichloromethane and methanol, followed by recrystallization from diisopropyl ether, 0.168 g of pure product is obtained in the form of a white solid.

Sources & evidence

ORD record
ord-e71f0728efad4a79a364944fd4cea559
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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