Ammonia → HCID 58861251, compound

HRID 1663041Notes

Reaction equation

HRID 1663041 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18][N:19]2[C:23](=[O:24])[CH2:22][O:21][C:20]2=[O:25])[CH2:13][CH2:12]1.[NH3:26]>CO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18][NH:19][C:20](=[O:25])[O:21][CH2:22][C:23]([NH2:26])=[O:24])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21096916HCID 21096916, compound

Product 1

HCID 58861251HCID 58861251, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The process is performed according to the procedure described in Example 3 (step 3.4). Starting with 1.14 g (3.36 mmol) of 3{2-[1-(2-quinolyl)-4-piperidyl]ethyl}-1,3-oxazolidine-2,4-dione, described in Example 8 (step 8.2), and 9.60 ml (67.20 mmol) of a solution (7M) of aqueous ammonia in methanol, and after chromatography on silica gel, eluting with a 95/5 mixture of dichloromethane and methanol, followed by recrystallization from ethyl acetate, 0.360 g of pure product is obtained in the form of a white solid.

Workup

  1. washafter chromatography on silica gel, eluting with a 95/5 mixture of dichloromethane and methanol
  2. customfollowed by recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-08c9c43461734adda02831900eabcefe
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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