4-Piperidineethanol → HCID 21096922, compound

HRID 1663054Notes

Reaction equation

HRID 1663054 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[Cl:12])[N:3]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]1>>[Cl:12][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][C:2]([N:13]1[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]1)=[N:3]2

Participants

3

Reactant 2

HCID 739534-PiperidineethanolHCID 6765522,5-Dichloroquinoline

Product 1

HCID 21096922HCID 21096922, compound

Procedure

The process is performed as described in Example 4 (step 4.1). Starting with 4.78 g (24.14 mmol) of 2-chloro-5-chloroquinoline (J. Med. Chem., 2002, 45, 3130-3137) and 3.43 g (26.55 mmol) of 2-(4-piperidyl)ethanol, 7 g of product are obtained in the form of an oil, which is used without further purification in the following step.

Workup

  1. customare obtained in the form of an oil, which
  2. customis used without further purification in the following step

Sources & evidence

ORD record
ord-db384a4059b542e98f90cbe317a2c6db
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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