4-Pyridinecarboxaldehyde → HCID 58989996, compound

Participants

Reaction Steps

To a stirred mixture of 2-amino-4-fluorobenzoic acid (Aldrich, 2.0 g) and pyridine-4-carbaldehyde (1.21 ml) in 1,2-dichloroethane (20 ml) was added sodium triacetoxy-borohydride (4.1 g). The reaction mixture was stirred at room temperature for 18 hours. Silica gel was added and the solvent was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (elution with EtOAc/methanol 19/1, v/v) and gave the title compound (1.04 g). 13C-NMR (DMSO-d6) δ 169.1, 166.2, 152.5, 149.6, 148.2, 134.6, 121.9, 107.6, 102.1, 97.7, 44.6.

Provenance & Evidence