Styrylboronic acid → 2-[(Pyridin-4-ylmethyl)-amino]-N-(2-styryl-benzyloxy)-benzamide

HRID 1663130Notes

Reaction equation

HRID 1663130 reaction equation
I[C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][O:5][NH:6][C:7](=[O:22])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][CH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1.[C:27]1(/[CH:33]=[CH:34]/B(O)O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[N:19]1[CH:20]=[CH:21][C:16]([CH2:15][NH:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7]([NH:6][O:5][CH2:4][C:3]2[CH:23]=[CH:24][CH:25]=[CH:26][C:2]=2[CH:34]=[CH:33][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:22])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 5702628Styrylboronic acidHCID 11487973N-((2-iodobenzyl)oxy)-2-((pyridin-4-ylmethyl)amino)benzamide

Product 1

HCID 729717812-[(Pyridin-4-ylmethyl)-amino]-N-(2-styryl-benzyloxy)-benzamide

Procedure

Starting materials: N-(2-Iodo-benzyloxy)-2-[(pyridin-4-ylmethyl)-amino]-benzamide (example 360) and trans-2-phenylvinylboronic acid (Aldrich).

Sources & evidence

ORD record
ord-765cdd839a0141228aed33f4b742ea7d
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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