HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Prop-2-ynyloxy)ethyl acetate → Acetic acid 2-[3-(2-{2-[(pyridin-4-ylmethyl)-amino]-benzoylaminooxymethyl}-phenyl)-prop-2-ynyloxy]-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Prop-2-ynyloxy)ethyl acetate | HCID 2780140 | — |
| Reactant | N-((2-iodobenzyl)oxy)-2-((pyridin-4-ylmethyl)amino)benzamide | HCID 11487973 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Product | Acetic acid 2-[3-(2-{2-[(pyridin-4-ylmethyl)-amino]-benzoylaminooxymethyl}-phenyl)-prop-2-ynyloxy]-ethyl ester | HCID 11317445 | — |
Reaction Steps
The same procedure was used as described for the preparation of example 365, but without addition of tetrabutylammonium iodide. Starting materials: N-(2-Iodo-benzyloxy)-2-[(pyridin-4-ylmethyl)-amino]-benzamide (see example 360) and 2-(prop-2-ynyloxy)ethyl acetate (Maybridge).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034811B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-40ccea6139eb4fa291587f29ff377a17 |
| Source note | uspto-grants-2011_10 |