2-Thiopheneboronic acid → 2-[(Pyridin-4-ylmethyl)-amino]-N-(2-thiophen-2-yl-benzyloxy)-benzamide

HRID 1663146Notes

Reaction equation

HRID 1663146 reaction equation
I[C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][O:5][NH:6][C:7](=[O:22])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][CH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1.[S:27]1[CH:31]=[CH:30][CH:29]=[C:28]1B(O)O>>[N:19]1[CH:20]=[CH:21][C:16]([CH2:15][NH:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7]([NH:6][O:5][CH2:4][C:3]2[CH:23]=[CH:24][CH:25]=[CH:26][C:2]=2[C:28]2[S:27][CH:31]=[CH:30][CH:29]=2)=[O:22])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 11487973N-((2-iodobenzyl)oxy)-2-((pyridin-4-ylmethyl)amino)benzamide

Product 1

HCID 113389992-[(Pyridin-4-ylmethyl)-amino]-N-(2-thiophen-2-yl-benzyloxy)-benzamide

Procedure

Prepared by a similar procedure as described for preparation of example 363. Starting materials: N-(2-Iodo-benzyloxy)-2-[(pyridin-4-ylmethyl)amino]-benzamide (see example 360) and thiophene-2-boronic acid (Aldrich).

Workup

  1. customPrepared by a similar procedure
  2. customas described for preparation of example 363

Sources & evidence

ORD record
ord-48af6c46b4af4cd691a408cdb78b3092
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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