O-(5-Chloro-thiophen-2-ylmethyl)-hydroxylamine → HCID 11406179, compound

HRID 1663151Notes

Reaction equation

HRID 1663151 reaction equation
FC1C(O[C:9](=[O:24])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][CH2:17][C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)=C(F)C(F)=C(F)C=1F.[Cl:29][C:30]1[S:34][C:33]([CH2:35][O:36][NH2:37])=[CH:32][CH:31]=1>>[Cl:29][C:30]1[S:34][C:33]([CH2:35][O:36][NH:37][C:9](=[O:24])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][CH2:17][C:18]2[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 10986580O-(5-Chloro-thiophen-2-ylmethyl)-hydroxylamineHCID 58989934HCID 58989934, compound

Product 1

HCID 11406179HCID 11406179, compound

Procedure

Prepared by the same method as described for example 415. Starting materials: 2-[(Pyridin-4-ylmethyl)-amino]-benzoic acid pentafluorophenyl ester (preparation 7C) and O-(5-chloro-thiophen-2-ylmethyl)-hydroxylamine (see preparation 64).

Workup

  1. customPrepared by the same method

Sources & evidence

ORD record
ord-271c68b0bd4446229fa4011e0fceeea4
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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