Acetate → 4-cyclopropyl-N-[3-methyl-5-(1,3-thiazol-5-yl)phenyl]pyrimidin-2-amine

HRID 166317Notes

Reaction equation

HRID 166317 reaction equation
[C:14](=[O:15])([O-:16])[O-:17].[CH3:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][c:7](-[c:9]2[cH:10][n:11][cH:12][s:13]2)[cH:8]1.[Cl:20][c:21]1[n:22][cH:23][cH:24][c:25]([CH:27]2[CH2:28][CH2:29]2)[n:26]1.[Cs+:18].[Cs+:19].[O-:31][C:32]([CH3:33])=[O:34].[O-:35][C:36]([CH3:37])=[O:38].[O:39]1[CH2:40][CH2:41][O:42][CH2:43][CH2:44]1.[Pd+2:30]>>[CH3:1][c:2]1[cH:3][c:4]([NH:5][c:21]2[n:22][cH:23][cH:24][c:25]([CH:27]3[CH2:28][CH2:29]3)[n:26]2)[cH:6][c:7](-[c:9]2[cH:10][n:11][cH:12][s:13]2)[cH:8]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 249019152-Chloro-4-cyclopropylpyrimidineHCID 58456365HCID 58456365, compound

Product 1

HCID 584561394-cyclopropyl-N-[3-methyl-5-(1,3-thiazol-5-yl)phenyl]pyrimidin-2-amine

Sources & evidence

ORD record
ord-48f4ed9884974b2ab1b8930fe1c794f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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