Ammonium Hydroxide → HCID 57926938, compound

Participants

Reaction Steps

To a suspension of 5-bromoisobenzofuran-1(3H)-one III-1 (6.57 g, 30.1 mmol) in MeOH (140 mL) was added NH4OH (60 mL). The reaction vessel was sealed and stirred for 36 h. The reaction was The reaction was concentrated under vacuum to afford 4-bromo-2-(hydroxymethyl)benzamide (7.10 g, 99%) as a white solid; 1H-nmr (400 MHz, CDCl3) δ 7.80 (d, J=8.5 Hz, 1H), 7.70 (s, 1H), 7.68 (s, 2H), 7.61 (s, 1H), 7.59-7.50 (m, 2H), 6.34 (br s, 1H), 5.72 (br s, 1H), 4.64 (s, 2H); LC (254 nM) 1.12 min (>98%); MS (ESI) m/z=231.8.

Provenance & Evidence