Hydrochloric Acid → HCID 7068523, compound

Participants

Reaction Conditions

Reaction Steps

Refer to Scheme 1, a mixture of methyl 2-isocyanatobenzoate (0.5 g, 2.82 mmol) and (S)-methyl leucinate HCl (0.52 g, 2.82 mmol) salt and 1 mL of Et3N was heated to 80° C. for 2 hours. 2 mL of 2M NaOH aqueous solution was added to above mixture and then heated to 100° C. overnight. The mixture was neutralized with concentrated HCl. Extracted by EtOAc and dried over MgSO4. Removing solvent gave the crude product, which used for next step without further purification. [M+H] calc'd for C14H16N2O4, 277; found, 277.

Provenance & Evidence