HCID 67436512, compound → HCID 178520143, compound

HRID 1663245Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]2[CH:25]([CH2:26][C:27]([OH:29])=O)[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]2=3)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.Cl.[N:32]1([CH2:37][CH2:38][C@H:39]2[CH2:44][CH2:43][C@H:42]([NH2:45])[CH2:41][CH2:40]2)[CH2:36][CH2:35][CH2:34][CH2:33]1>>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]2[CH:25]([CH2:26][C:27]([NH:45][C@H:42]3[CH2:43][CH2:44][C@H:39]([CH2:38][CH2:37][N:32]4[CH2:36][CH2:35][CH2:34][CH2:33]4)[CH2:40][CH2:41]3)=[O:29])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]2=3)(=[O:10])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 67436512HCID 67436512, compound

HCID 178478709HCID 178478709, compound

Product 1

HCID 178520143HCID 178520143, compound

Procedure

The title compound was prepared from [5-(3,4-dichloro-benzenesulfonyl)-5,6-dihydro-phenanthridin-6-yl]-acetic acid (Example 2c) and trans-4-(2-pyrrolidin-1-yl-ethyl)-cyclohexylamine dihydrochloride (Reference Example 4) according to the method described in Example 1e. MS (EI) 627.2 (MH+).

Sources & evidence

ORD record: ord-fd046e7219b64cb3b4459c22e1cde13d
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08034827B2

Reaction notes

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