tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate → HCID 67437381, compound

HRID 1663253Notes

Reaction equation

HRID 1663253 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]2[CH:25]([CH2:26][C:27]([NH:29][CH2:30][C:31](O)=[O:32])=[O:28])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]2=3)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[C:34]([O:38][C:39]([N:41]1[CH2:46][CH2:45][CH:44]([CH2:47][CH2:48][NH2:49])[CH2:43][CH2:42]1)=[O:40])([CH3:37])([CH3:36])[CH3:35]>>[C:34]([O:38][C:39]([N:41]1[CH2:46][CH2:45][CH:44]([CH2:47][CH2:48][NH:49][C:31](=[O:32])[CH2:30][NH:29][C:27](=[O:28])[CH2:26][CH:25]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]2[S:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)(=[O:10])=[O:11])[CH2:43][CH2:42]1)=[O:40])([CH3:37])([CH3:36])[CH3:35]

Participants

3

Reactant 2

HCID 1514258tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylateHCID 67436261N-[2-[5-[(3,4-Dichlorophenyl)sulfonyl]-5,6-dihydro-6-phenanthridinyl]acetyl]glycine

Product 1

HCID 67437381HCID 67437381, compound

Procedure

The title compound was prepared from {2-[5-(3,4-dichloro-benzenesulfonyl)-5,6-dihydro-phenanthridin-6-yl]-acetylamino}-acetic acid (Example 12b) and 4-(2-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester according to the method described in Example 1e.

Sources & evidence

ORD record
ord-a7f163ab344c449581b079556cbb8e57
Source dataset
uspto-grants-2011_10
Patent number
US08034827B2

Reaction notes

Loading…