Trifluoroacetic acid → HCID 66625149, compound

Participants

Reaction Steps

2-Amino-thiophene-3-carbonitrile (30 mg) and 5-nitro-thiophene-2-carboxaldehyde (41 mg) were mixed in isopropanol with TFA and refluxed for 28 hours. The reaction was then purified by flash chromatography, resulting in 45 mg (71%) of the title compound as an orange powder. M.p.: 192°-194° C. 1H-NMR (300 MHz, [D]acetone): δ=8.98 (s, 1H), 8.12 (d, 1H, 3J=4.3 Hz), 7.85 (d, 1H, 3J=4.3 Hz), 7.61 (d, 1H, 3J=5.7 Hz), 7.38 (d, 1H, 3J=5.7 Hz). 13C-NMR (300 MHz, [D] acetone): δ=161.2, 154.3, 147.3, 133.7, 130.0, 128.6, 125.9, 125.1, 109.5, 108.5.

Provenance & Evidence