Ethanol → HCID 66626477, compound

Participants

Reaction Steps

One-step synthesis of the title compound can be achieved by combining 2,5-diaminothiophene-3,4-dicarboxylate (15 mg, 0.5 mmol) with 2-thiophene carboxaldehyde (6.5 mg, 0.6 mmol), followed by refluxing in ethanol for 12 hours in the presence of a catalytic amount of TFA. After removal of the solvent, 5-(thiophen-2-yl)thiophene-2-carbaldehyde (11.3 mg, 0.5 mmol) in isopropanol was added in addition to a catalytic amount of TFA and the solution refluxed for 12 hours. The title compound was isolated as a red powder (20.9 mg, 0.4 mmol, 63%) after flash chromatography (SiO2).

Provenance & Evidence