反应详情

温度

-3 °C

4-(4-Fluorophenyl)-6-isopropylpyrimidin-2-ol (8.00 g, 34.1 mmol) was charged to a reactor followed by DMF (100 mL). The suspension was stirred, cooled to −3° C. and N-bromosuccinimide (6.25 g, 34.8 mmol) added. The reaction mixture was warmed to 20° C. and stirred overnight. Water (100 mL) was charged to the reaction mixture and the crystalline mixture stirred for 1 hour before filtering off. The isolated solid was washed twice with water (25 mL) and the solid dried in a vacuum oven at 50° C. 5-Bromo-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-ol (10.45 g, 97% yield) was obtained as a white solid;

1. temperatureThe reaction mixture was warmed to 20° C.
2. stirringstirred overnight
3. stirringthe crystalline mixture stirred for 1 hour
4. filtrationbefore filtering off
5. washThe isolated solid was washed twice with water (25 mL)
6. customthe solid dried in a vacuum oven at 50° C