HCID 59756821, compound → HCID 59756818, compound

Participants

Reaction Steps

A 2-necked round bottom flask was charged with 0.56 g (2.0 mmol) 1′-benzyl-7H-spiro[furo[3,4-b]pyridine-5,4′-piperidine] and 20 ml 2,2,2-trifluoroethanol. The reaction mixture was purged with argon prior to adding 0.21 g (10 mol-%) palladium on activated charcoal. The flask was evacuated, refilled with hydrogen and stirred for 16 h. The catalyst was filtered off and washed with ethanol. The filtrate was concentrated to dryness to give the title compound (0.43 g, quantitative, purity of approx. 90%) as a light brown solid.

Provenance & Evidence