HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → HCID 67437324, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 67434806 | HCID 67434806 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67437324 | HCID 67437324 | — |
Reaction Steps
A mixture of 4-{[2-bromo-4-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-6-(propane-1-sulfonylamino)-phenylamino]-methyl}-benzoic acid (200 mg), TBTU (300 mg), N,N-diisopropylethylamine (536 μl) and 2-methoxyethylamine (134 μl) in DMF (2 ml) was stirred for 2 h at room temperature. The mixture was diluted with ethyl acetate and washed with aq. NaHCO3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034945B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-562b65b8004943d2b035ec914f7b58d1 |
| Source note | uspto-grants-2011_10 |