HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1663381Generated: October 30, 2026
5-Propylcyclohexane-1,3-dione → 3-Bromo-5-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-2-(3-methoxy-benzyloxy)-benzoic acid methyl ester
https://huagongshe.com/reaction/1663381
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Propylcyclohexane-1,3-dione | HCID 2737224 | — |
| Reactant | 3-Aminocrotonitrile | HCID 5324720 | — |
| Reactant | HCID 87399760 | HCID 87399760 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Bromo-5-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-2-(3-methoxy-benzyloxy)-benzoic acid methyl ester | HCID 67435033 | — |
Reaction Steps
A mixture of 3-bromo-5-formyl-2-(3-methoxy-benzyloxy)-benzoic acid methyl ester (3.78 g), 3-aminocrotonitrile (822 mg) and 5-propylcyclohexane-1,3-dione (1535 mg) in ethanol (25 ml) was stirred at 80° C. for 17 h. The mixture was concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08034945B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-3811951a560c485eaa3826507e8e39ee |
|---|
| Source note | uspto-grants-2011_10 |
|---|
