Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 67435389 | HCID 67435389 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67435435 | HCID 67435435 | — |
Reaction Steps
A mixture of 4-[3-bromo-5-hydroxy-4-(3-methoxy-benzyloxy)-phenyl]-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile (100 mg), 2-bromoethanol (16 μl), tetrabutylammonium iodide (5 mg) and potassium carbonate (50 mg) in DMF (2 ml) was stirred at 70° C. for 17 h. The mixture was diluted with ethyl acetate and washed with water. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08034945B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-64806c67ffbe4048b7837dbf1f90c4f9 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
