Hydrochloric Acid → HCID 67435400, compound

Participants

Reaction Steps

A 1 N aqueous solution of NaOH (5 mL, 5.00 mmol) was added to a solution of the product from Step 1 (250 mg, 0.564 mmol) in MeOH (10 mL) at room temperature. After 24 h at 80° C., the mixture was cooled to room temperature and adjusted pH2-3 with 1 N aqueous HCl. MeOH was evaporated in vacuo. The brown precipitate in the aqueous residue was collected by filtration and dried under vacuum to give 4-(5-(1-carboxycyclobutyl)-5H-chromeno[2,3-b]pyridin-2-yl)benzoic acid (210 mg, 93%). MS (ES+) m/z: 402 (M+H).

Provenance & Evidence