1,2-Dichloroethane → HCID 67436193, compound

Participants

Reaction Steps

HOBt (145 mg, 0.945 mmol), EDC (181 mg, 0.945 mmol) and Hunig's base (0.550 mL, 3.15 mmol) were added to a suspension of 4-(10-oxo-10H-chromeno[3,2-c]pyridin-3-yl)benzoic acid (200 mg, 0.630 mmol) in DMF (15 mL) and CH2Cl2 (10 mL) at room temperature. After 5 min, morpholine (0.110 mL, 1.261 mmol) was added. After 13 h at rt, the mixture was quenched with saturated NH4Cl (50 mL) and extracted with CH2Cl2 (3×50 mL). The combined extracts were dried (MgSO4) and concentrated to give crude 3-(4-(morpholine-4-carbonyl)phenyl)-10H-chromeno[3,2-c]pyridin-10-one, which was taken to next reaction without purification. MS (ES+) m/z: 387 (M+H).

Provenance & Evidence