Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Fluoroaniline | HCID 9742 | — |
| Reactant | (Z)-4-amino-N-hydroxy-1,2,5-oxadiazole-3-carbonimidoyl chloride | HCID 4040027 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178509309 | HCID 178509309 | 29% |
Reaction Steps
A solution of 3-fluoroaniline (36 μL, 0.37 mmol) in ethanol (0.5 mL) was treated with a solution of 4-amino-N-hydroxy-1,2,5-oxadiazole-3-carboximidoyl chloride (50 mg, 0.31 mmol) in ethanol (1.5 mL) followed by triethylamine (51 μL, 0.37 mmol) dropwise. The reaction mixture was stirred at 25° C. for 1 h and purified by preparative LCMS to give the desired product (21 mg, 29%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08034953B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-70817fc766c14a1e9e737891a8a1bae7 |
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| Source note | uspto-grants-2011_10 |
|---|
