3,3-Dimethylbutanal → Aspartame

Participants

Reaction Steps

In a third embodiment of the present invention, neotame is synthesized by regenerating 3,3-dimethylbutyraldehyde from a hydrazone, semicarbazone or oxime of 3,3-dimethylbutyraldehyde by acidic hydrolysis or by oxidative cleavage in a solvent or a mixture of solvents and then adding aspartame under hydrogenation conditions with a catalyst to produce neotame.

Provenance & Evidence