HCID 57310848, compound → HCID 15546052, compound

Participants

Reaction Steps

To a solution of compound 43 (0.35 g, 0.8 mmol) in absolute ethanol (2 cm3) was added 20% palladium hydroxide over carbon (0.37 g) and the mixture was degassed several times with hydrogen and stirred under the atmosphere of hydrogen for 4 h. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography using dichloramethane/methanol (9:1, v/v) as eluent to give nucleoside 44 as a white solid material (0.16 g, 78%). δH (CD3OD) 7.88 (1H, d, J 8.1, 6-H), 5.69 (1H, d, J 8.1, 5-H), 5.55 (1H, s, 1′-H), 4.28 (1H, s, 2′-H), 4.04 (1H, s, 3′-H), 3.96 (1H, d, J 7.9, 1″-Ha), 3.91 (2H, s, 5′-H), 3.76 (1H, d, J 7.9, 1″-Hb). δC (CD3OD) 172.95 (C-4), 151.82 (C-2), 141.17 (C-6), 101.97 (C-5), 90.52, 88.50 (C-1′, C-4′), 80.88, 72.51, 70.50, 57.77 (C-2′, C-3′, C-5′, C-1″). FAB-MS m/z 257 [M+H]+.

Provenance & Evidence