HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → CBr4 triphenylphosphine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1-[(1S)-1-(tertbutoxycarbonyl)propyl]-5-oxo-3-pyrrolidinecaboxaldehyde | HCID 18346116 | — |
| Product | CBr4 triphenylphosphine | HCID 11387777 | — |
Reaction Steps
Alternatively to §6.2.3., halovinyl derivatives can be obtained by Wittig olefination of the 1-[(1S)-1-(tertbutoxycarbonyl)propyl]-5-oxo-3-pyrrolidinecarboxaldehyde 396 in the presence of a phosphine and an halogenomethane. For example, (2S)-2-(2-oxo-4-(2,2-dibromovinyl)-1-pyrrolidinyl)butanoic acid 2,2-(dimethyl)ethyl ester is obtained from aldehyde 396 and CBr4 in the presence of triphenylphosphine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034958B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-0b9baa360e5f4311b0b636b57f265263 |
| Source note | uspto-grants-2011_10 |