HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 9946598, compound → HCID 9813018, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 9946598 | HCID 9946598 | — |
| Reactant | HCID 22387035 | HCID 22387035 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 9813018 | HCID 9813018 | — |
Reaction Steps
Alternatively, 2-(4-bromo-ethynyl-2-oxo-1-pyrrolidinyl)butanamide 267 is obtained by reacting 2-[4-(2,2-dibromovinyl)-2-oxo-1-pyrrolidinyl]butanamide 47 with two equivalent of potassium tertbutoxide in THF at low temperature (−50° C. to 0° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034958B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-82f1b6f50bd144e89fb54828045e5223 |
| Source note | uspto-grants-2011_10 |