反应详情

温度

70 °C

To 222 g (1.0 mol) of 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane was added 400 g of distilled water, and the whole was adjusted to pH 2 with phosphoric acid. With introduction of nitrogen thereinto, the solution was heated to 70° C. After 2 hours of reaction, the solution was adjusted to pH 7.0 with sodium hydroxide. Thereto was charged 1 L of chloroform and extraction was carried out. Then, the chloroform layer was dried over magnesium sulfate and concentrated. Thereafter, the concentrate was filtrated to remove salts, and thereby 3-benzyloxy-1,2-propanediol was obtained. The NMR data thereof are the same as those in Example 1-2.

1. customAfter 2 hours of reaction
2. additionThereto was charged
3. extraction1 L of chloroform and extraction
4. dry with materialThen, the chloroform layer was dried over magnesium sulfate
5. concentrationconcentrated
6. filtrationThereafter, the concentrate was filtrated
7. customto remove salts