4-(Dimethylsulfamoyl)benzoic acid → 4-(N,N-dimethylsulfamoyl)benzoyl chloride

HRID 1663598Notes

Reaction equation

HRID 1663598 reaction equation
[CH3:1][N:2]([CH3:15])[S:3]([C:6]1[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][CH:7]=1)(=[O:5])=[O:4].S(Cl)([Cl:18])=O>>[CH3:1][N:2]([CH3:15])[S:3]([C:6]1[CH:14]=[CH:13][C:9]([C:10]([Cl:18])=[O:11])=[CH:8][CH:7]=1)(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 145724-(Dimethylsulfamoyl)benzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 47367944-(N,N-dimethylsulfamoyl)benzoyl chloride

Conditions

Temperature
90 °C

Procedure

A mixture of 4-dimethylsulfamoylbenzoic acid (688 mg) and thionyl chloride (5 mL) was stirred at 90° C. overnight. The reaction mixture was concentrated to give 4-dimethylsulfamoylbenzoyl chloride (495 mg) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-1c041bcb11874842a97474a2a3d7458c
Source dataset
uspto-grants-2011_10
Patent number
US08034949B2

Reaction notes

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