HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(2-bromoethyl) ether → methyl 3-(4-cyanotetrahydro-2H-pyran-4-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(2-bromoethyl) ether | HCID 21521 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 3-(cyanomethyl)benzoate | HCID 10821136 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | methyl 3-(4-cyanotetrahydro-2H-pyran-4-yl)benzoate | HCID 57441036 | 46.5% |
Reaction Steps
Using methyl 3-(cyanomethyl)benzoate (1.0 g, 5.7 mmol), sodium hydride (60% in oil, 0.69 g, 17 mmol), bis(2-bromoethyl)ether (1.8 g, 6.9 mmol) and dimethyl sulfoxide (12 mL) as starting materials and in the same manner as in Reference Example 31, the title compound (650 mg, 46%) was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034812B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-4c648aed3cc64cdfb9a721cabb326080 |
| Source note | uspto-grants-2011_10 |