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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1663660Generated: October 30, 2026

2-Methyl-2-(3-nitrophenyl)propanenitrile → 2-(3-Aminophenyl)-2-methylpropanenitrile

https://huagongshe.com/reaction/1663660

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2-(3-nitrophenyl)propanenitrileHCID 15541324—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
Product2-(3-Aminophenyl)-2-methylpropanenitrileHCID 56965787100%

Reaction Steps

To a solution of 2-methyl-2-(3-nitrophenyl)propanenitrile (0.35 g, 1.8 mmol) in ethyl acetate (10 mL) was added 10% palladium/carbon (35 mg), and the mixture was stirred for 10 hr under hydrogen atmosphere. The residual catalyst was filtered through celite, and washed with ethyl acetate. The filtrate was concentrated under reduced pressure to give the title compound (0.35 g, 1.8 mmol) as a pale-yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08034812B2
Source datasetuspto-grants-2011_10
ORD IDord-bf55956fdf6149d3a25fa68627269d04
Source noteuspto-grants-2011_10