Sodium Hydroxide → 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 1663677Notes

Reaction equation

HRID 1663677 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]([O:13]C)=[O:12])[N:8]([CH3:15])[N:7]=1.[OH-].[Na+]>CO>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[N:8]([CH3:15])[N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57441051methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 574410523-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylic acidYield 96.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate (3.03 g, 14.1 mmol), methanol (15 mL) and 8N aqueous sodium hydroxide solution (3.00 mL), and in the same manner as in Reference Example 58, the title compound (2.72 g, yield 96%) was obtained.

Sources & evidence

ORD record
ord-31d03f8b9d3a4a7ca3445f873697b8c8
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Reaction notes

Loading…