HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-[6-(5-amino-2-methoxyphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Amino-2-methoxyphenol | HCID 74314 | — |
| Reactant | N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide | HCID 57386058 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[6-(5-amino-2-methoxyphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide | HCID 57505485 | 36.1% |
Reaction Steps
Using N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (800 mg, 2.44 mmol), 5-amino-2-methoxyphenol (408 mg, 2.93 mmol), potassium carbonate (843 mg, 6.10 mmol) and N,N-dimethylformamide (6.0 mL) as starting materials and in the same manner as in Example 91, the title compound (299 mg, 36%) was obtained as a brown powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034812B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-5be50253bb604573bea435949b19ebbe |
| Source note | uspto-grants-2011_10 |