HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → N-(6-phenoxyimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide | HCID 57386058 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(6-phenoxyimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide | HCID 57505580 | 54.6% |
Reaction Steps
Using phenol (69 mg, 0.73 mmol), N,N-dimethylformamide (25.0 mL), potassium tert-butoxide (1.16 g, 10.3 mmol), N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (200 mg, 0.61 mmol) and potassium carbonate (42 mg, 0.31 mmol), and in the same manner as in Example 216, the title compound (98 mg, 54%) was obtained as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034812B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-03950b31a68d4c9ea732777256364041 |
| Source note | uspto-grants-2011_10 |