Potassium Carbonate → N-[6-(3-amino-6-chloro-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	5-Amino-2-chloro-4-fluorophenol	HCID 158654	—
Reactant	N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide	HCID 57386058	—
Solvent	Dimethylformamide	HCID 6228	—
Product	N-[6-(3-amino-6-chloro-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide	HCID 57505449	56.2%

Reaction Steps

To a solution of N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (600 mg, 1.83 mmol) in N,N-dimethylformamide (12 mL) were added 3-amino-6-chloro-4-fluorophenol (443 mg, 2.74 mmol) and potassium carbonate (505 mg, 3.66 mmol). In the same manner as in Example 232, the title compound (372 mg, 56%) was obtained as a brown powder.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08034812B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-7855f2bdd28f4f9bbb6aabfae0123a56
Source note	uspto-grants-2011_10