HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → N-[3-({2-[(morpholin 4-ylacetyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | N-[3-({2-[(chloroacetyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(trifluoromethyl)benzamide | HCID 57505744 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-[3-({2-[(morpholin 4-ylacetyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(trifluoromethyl)benzamide | HCID 57505745 | 87% |
Reaction Steps
Using N-[3-({2-[(chloroacetyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(trifluoromethyl)benzamide (120 mg, 0.244 mmol), morpholine (1 mL) and acetonitrile (3 mL) as starting materials and in the same manner as in Example 398, the title compound (116 mg, 87%) was obtained as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034812B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d9d1e7a546104e24958b0b1cf631433a |
| Source note | uspto-grants-2011_10 |