Hydrochloric Acid → HCID 21069816, compound

Participants

Reaction Steps

To a solution of 2-azidomethyl-5-fluoro-N-methyl-benzenesulfonamide (560 mg, 2.3 mmol) in ethanol (10 mL) was added 6N HCl (1 mL) and 10% Pd—C (100 mg) and the mixture hydrogenated with 1 atm of H2 for 14 hrs. The catalyst was removed by filtration through Celite® and the filtrate concentrated in vacuo to provide 630 mg (Yield >100%) of the title compound. 1H NMR (500 MHz, DMSO-D6) δ ppm: 4.36 (2H, d, J=5.2 Hz) 7.63-7.70 (2H, m) 7.77-7.83 (1H, m) 8.11 (1H, d, J=4.9 Hz) 8.41 (3H, s); LC/MS m/z 219 (M+H).

Provenance & Evidence