Hydrochloric Acid → 2-(1,1-Dioxo-1lambda6-[1,2]thiazinan-2-yl)benzylamine hydrochloride

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Reaction Steps

2-(1,1-Dioxo-1λ6-[1,2]thiazinan-2-yl)benzonitrile, (2.63 g, 11.14 mmol) was dissolved in ethanol (150 mL) and 1N HCl (13 mL). 10% Pd—C (0.5 g) was added and the mixture shaken under H2 at 55 psi for 24 h. Filtration through Celite® followed by concentration gave the title compound as a white solid (2.93 g, 95% yield). 1H-NMR (300 MHz, CD3OD) δ ppm: 7.61-7.47 (4H, m), 4.30 (2H, q, J=13.7 Hz), 3.96-3.87 (1H, m), 3.49-3.36 (3H, m), 2.40-2.31 (2H, m), 2.05-1.96 (2H, m). LCMS [M+H]+ calcd for C11H17N2SO2: 241.10; found: 241.10.

Provenance & Evidence