HCID 58877841, compound → HCID 54705118, compound

Participants

Reaction Steps

To a solution of 3′-(benzyloxy)-N-(4-fluoro-2-(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)benzyl)-4′-oxo-2,3,4′,5,6,6′,7′,9′-octahydrospiro[pyran-4,10′-pyrimido[1,2-d][1,4]oxazepine]-2′-carboxamide (0.093 g, 0.174 mmol) in ethyl acetate (5 mL) was added palladium on activated carbon (10%) (0.050 g) and the resulting mixture allowed to react under one atmosphere of hydrogen for 6 hours. The catalyst was removed by filtration and the filtrate was evaporated under reduce pressure to give a white solid. Recrystallization from hot ethanol afforded the title compound as a white solid (0.053 g, 68% yield): 1H NMR (400 MHz, CDCl3) δ 12.28 (1H, s), 8.95 (1H, brt), 7.66 (1H, dd, J=8.6, 6.1 Hz), 7.63 (1H, s), 7.22 (2H, dd, J=9.2, 2.8 Hz), 7.12 (2H, td, J=8.2, 2.8 Hz), 4.53 (2H, brs), 3.7-3.90 (10H, m), 3.43 (3H, s), 2.2-2.5 (2H, brm), 1.5-2.0 (2H, brm); LCMS (+ESI, M+H+) m/z 501.

Provenance & Evidence