HCID 67440066, compound → HCID 67440569, compound

HRID 1664205Notes

Reaction equation

HRID 1664205 reaction equation
[C:1]([O:5][C:6](=[O:34])[NH:7][C@@H:8]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([OH:33])[CH:28]=1)[C@H:9]([OH:25])[CH2:10][NH:11][C:12]1([C:15]2[CH:20]=[C:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:18]=[CH:17][N:16]=2)[CH2:14][CH2:13]1)([CH3:4])([CH3:3])[CH3:2].[CH3:35][O:36][C:37](=[O:55])[C:38]1[CH:43]=[C:42]([CH3:44])[N:41]=[C:40]([O:45][CH2:46][CH2:47][CH2:48][CH2:49]OS(C)(=O)=O)[CH:39]=1>>[CH3:35][O:36][C:37](=[O:55])[C:38]1[CH:43]=[C:42]([CH3:44])[N:41]=[C:40]([O:45][CH2:46][CH2:47][CH2:48][CH2:49][O:33][C:29]2[CH:30]=[CH:31][CH:32]=[C:27]([CH2:26][C@H:8]([NH:7][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:34])[C@H:9]([OH:25])[CH2:10][NH:11][C:12]3([C:15]4[CH:20]=[C:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:18]=[CH:17][N:16]=4)[CH2:14][CH2:13]3)[CH:28]=2)[CH:39]=1

Participants

3

Reactant 2

HCID 67440066HCID 67440066, compoundHCID 86626578HCID 86626578, compound

Product 1

HCID 67440569HCID 67440569, compound

Procedure

The product is prepared according to the method described in example 43 (step a), starting from [(1S,2R)-3-[1-(4-tert-butyl-pyridin-2-yl)cyclopropylamino]-2-hydroxy-1-(3-hydroxy-benzyl)-propyl]-carbamic acid tert-butyl ester (building block C16) and 2-(4-methanesulfonyloxy-butoxy)-6-methyl-isonicotinic acid methyl ester (building block E1).

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-2bff71fb7fcf40efbe876dbea3057d2a
Source dataset
uspto-grants-2011_10
Patent number
US08039455B2

Reaction notes

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