HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitro-5-oxazol-2-yl-benzoic acid methyl ester → 3-Amino-5-oxazol-2-yl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitro-5-oxazol-2-yl-benzoic acid methyl ester | HCID 67440703 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Amino-5-oxazol-2-yl-benzoic acid methyl ester | HCID 67439866 | — |
Reaction Steps
A solution of 11.7 g (47.1 mmol) of 3-nitro-5-oxazol-2-yl-benzoic acid methyl ester in 1 l of MeOH and 200 ml of THF is stirred under an atmosphere of hydrogen in the presence of 0.6 g of Pd/C (10%) until the hydrogen up-take ceases. The mixture is filtered over high-flow, and the filtrate is washed with THF and evaporated to yield the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039455B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-c00980911b51430a950ffa2981007356 |
| Source note | uspto-grants-2011_10 |