Isopropyl chloroformate → HCID 67441573, compound

Participants

Reaction Conditions

Reaction Steps

5-Benzyloxycarbonylamino-isophthalic acid monomethyl ester (10 g, 30.1 mmol, 1 eq) and Et3N (5 ml, 36.1 mmol, 1.2 eq) are suspended in a mixture of THF (200 ml) and N-methylpyrrolidone (200 ml). Isopropylchloroformate (42 ml, 1 N in toluene, 42 mmol, 1.4 eq) is added, and the reaction mixture is stirred for 30 min at 0° C. and then diluted with diethyl ether and water. The organic layer is washed with 0.1 N HCl and brine. NaBH4 (3.82 g, 101 mmol, 3.36 eq) is dissolved in H2O (100 ml), and the solution is added to the reaction mixture, which is then stirred for 1 h. Diethyl ether and H2O are added, and the organic layer is separated, washed with brine, dried over sodium sulfate, filtered and concentrated. The residue is purified by column chromatography using EtOAc/hexane in a ratio of 1 to 2 to give the product.

Provenance & Evidence