3-Amino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid → 3-Hydroxy-5-(2-oxopyrrolidin-1-yl)benzoic acid

Participants

Reaction Conditions

Reaction Steps

To the solution of 1.33 g (6.0 mmol) 3-amino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid in 15 ml water and 0.75 ml (13.3 mmol, 2.2 eq) concentrated sulfuric at 0° C. are added 0.56 g (8.2 mmol, 1.35 eq) sodium nitrit. After addition of 10 ml water the reaction is heated to 90° C. After cooling to rt the reaction is extracted with EtOAc, the organic layer is dried over sodium sulfate and the solvent is evaporated at reduced pressure to give the product.

Provenance & Evidence