Allyl bromide → 3-Allyloxy-4-fluoro-benzoic acid methyl ester

Participants

Reaction Steps

4-Fluoro-3-hydroxy-benzoic acid methyl ester (26.3 g, 154.5 mmol) is dissolved in acetone (300 ml). Potassium carbonate (42.7 g, 305.8 mmol) is added, followed 5 minutes later by the addition of allyl bromide (20 ml, 229 mmol). The reaction mixture is stirred overnight at rt, concentrated in vacuo and then diluted with ether and water. The organic layer is washed with saturated brine, dried over sodium sulfate, filtered and concentrated to give the product as a colourless oil.

Provenance & Evidence